AMYLODIDOSIS

-
AMYLOIDOSIS

Amyloidosis is the term used for a group of Fibrillar insoluble proteinaseous substance called amyloid having common morphological appearance, staining properties and physical structure but with variable protein composition (20-30 different proteins). 


⚛ Production of abnormal amount of proteins

⚛Production of normal amount of mutant production

🔹 Stimulus  ➡  Soluble precursor  ➡  Insoluble fibrils

🔹 Mutation  ➡  Mutant Tranthretin  ➡  ATTR Protein

Comments

Post a Comment

Popular posts from this blog

BLEEDING DISORDER

-
Image
BLEEDING DISORDERS If process of CLOTTING MECHANISM is known properly, very easy to diagnose the case and to treat to some extent.  ✴ Mechanism of action ✴ Laboratory investigations ▶Complete blood counts with peripheral smear examination  ▶ Screening tests for bleeding disorders ▶ Specific tests for factor deficiencies ▶ Platelet function tests  ▶ Other investigations as per requirements ✴ Screening tests for bleeding disorders ▶ Bleeding time, Clotting time ▶ Platelet Count ▶ Prothrombin time with INR (PT) ▶ Activated Partial Thromboplastin Time (aPTT) ▶ Thrombin time test (TT) ▶ Fibrinogen concentration ▶ F D P ✴Causes of bleeding disorders 1. Vascular defects 2. Platelet defects 3. Clotting mechanism defects 1. Acquired vascular defects 2. Congenital vascular defects
Read more